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Phloroglucinols with Antioxidant Activity and Xanthonolignoids from the Heartwood of Hypericum geminiflorum.

Wu CC, Yen MH, Yang SC, Lin CN

lincna@cc.kmu.edu.tw, yen@kmu.edu.tw.

A new phloroglucinol, hyperielliptone HA ( 1/ 1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB ( 2/ 2a), and two new xanthonolignoids, hyperielliptones HC ( 3) and HD ( 4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/ 1a and 2/ 2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/ 2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.

Published 30 June 2008 in J Nat Prod, 71(6): 1027-31.
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