St John's Wort Research Today is a free monthly online journal that collates and summarizes the latest research about St John's Wort, including details on depression, anxiety, side-effects, dosage, benefits.

Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.

Tanaka N, Kubota T, Ishiyama H, Araki A, Kashiwada Y, Takaishi Y, Mikami Y, Kobayashi J

Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.

Published 26 May 2008 in Bioorg Med Chem, 16(10): 5619-23.
Full-text of this article is available online (may require subscription).

© 2004-2008 St John's Wort Research Today. All Rights Reserved.