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Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice.

Oku H, Ueda Y, Iinuma M, Ishiguro K

School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

The inhibitory effects of 22 xanthones from three Guttiferae plants (Hypericum patulum, Calophyllum inophyllum and C. austroindium) on exogenous platelet activating factor (PAF)-induced hypotension were examined using a blood pressure monitoring in vivo assay method. Guanandin (2), caloxanthone E (3), 1,3,5,6-tetrahydroxy-2-isoprenylxanthone (8), 6-deoxyjacareubin (11) and patulone (18) showed strong inhibition of PAF-induced hypotension, with inhibitory effects of more than 60 %. Their ID50 values were greater than that of ginkgolide B (BN-52 021), a natural PAF-antagonist from the Ginkgo biloba.

Published 28 January 2005 in Planta Med, 71(1): 90-2.
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